Mannitol serves as a matrix forming additive for lyophilization.  When used at concentrations up to 10% w/v, mannitol forms an amorphous (non-crystaline) matrix which supports proteins and other biomolecules for freeze drying.  It is generally inert and once freeze dried, rehydrates rapidly.  It's amorphous structure while frozen prevents it from disrupting proteins while providing channels for water sublimation during processing.  OPS Diagnostics mannitol is USP grade, with each batch being certified for lyophilization.

Trehalose, a non-reducing disaccharide (two glucose molecules linked by the anomeric carbon), is an effective lyoprotectant for the freeze drying of proteins and other biomolecules.  During the freeze drying process, proteins can denature as water is removed unless a substitute molecule is available to support the structure of the protein.  Trehalose fills the void left by exiting water and prevents this denaturation.  When used at concentrations as little as 2% it can effectively protect proteins and other biomolecules.  OPS Diagnostics trehalose is tested and certified for use in freeze drying.

Sucrose, Lyophilization Certified, 500 gm

Size: 500 gm

Product Number: EXSU 500-03

Price: $89

Sucrose, like trehalose, is a non-reducing disaccharide (glucose linked by its anomeric carbon to fructose) that is widely used as a lyoprotectant.  Sucrose is the traditional lyoprotectant used in many formulations.  Each batch of sucrose at OPS Diagnostics is tested and certified for lyophilization.